Olopatadine, a non-sedating H1 antihistamine, decreases the nocturnal scratching without affecting sleep quality in atopic dermatitis

Exp Dermatol. 2015 Mar;24(3):227-9. doi: 10.1111/exd.12630.

Abstract

We have demonstrated for the first time that a second-generation antihistamine ameliorates nocturnal scratching behavior in atopic dermatitis patients using a modified wristwatch-type acoustic scratching counting system that we have recently developed. We also analyzed the sleep quality by simultaneous recording of electroencephalogram, and found that sleep quality was unaffected.

Keywords: antihistamine; atopic dermatitis; electroencephalogram; scratching; sleep quality.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dermatitis, Atopic / complications
  • Double-Blind Method
  • Electroencephalography
  • Histamine H1 Antagonists, Non-Sedating / therapeutic use*
  • Humans
  • Olopatadine Hydrochloride / therapeutic use*
  • Pruritus / drug therapy*
  • Pruritus / etiology
  • Severity of Illness Index
  • Sleep Stages / physiology*
  • Time Factors
  • Visual Analog Scale

Substances

  • Histamine H1 Antagonists, Non-Sedating
  • Olopatadine Hydrochloride