Vitamin K2 for the reversal of warfarin-related coagulopathy

Toru Hifumi; Hiroaki Takada; Daisuke Ogawa; Kenta Suzuki; Hideyuki Hamaya; Natsuyo Shinohara; Yuko Abe; Koshiro Takano; Kenya Kawakita; Masanobu Hagiike; Yuichi Koido; Yasuhiro Kuroda

doi:10.1016/j.ajem.2015.01.002

Vitamin K2 for the reversal of warfarin-related coagulopathy

Am J Emerg Med. 2015 Aug;33(8):1108.e1-3. doi: 10.1016/j.ajem.2015.01.002. Epub 2015 Jan 13.

Authors

Toru Hifumi¹, Hiroaki Takada², Daisuke Ogawa³, Kenta Suzuki⁴, Hideyuki Hamaya⁵, Natsuyo Shinohara⁶, Yuko Abe⁷, Koshiro Takano⁸, Kenya Kawakita⁹, Masanobu Hagiike¹⁰, Yuichi Koido¹¹, Yasuhiro Kuroda¹²

Affiliations

¹ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: hifumitoru@gmail.com.
² Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center, Tokyo, 190-0014, Japan. Electronic address: hiroaki_takada@msn.com.
³ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: ohio@kms.ac.jp.
⁴ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: flying1369@yahoo.co.jp.
⁵ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: hidedoc@med.kagawa-u.ac.jp.
⁶ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: natsuyot@med.kagawa-u.ac.jp.
⁷ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: abekulo@med.kagawa-u.ac.jp.
⁸ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: ktakano@med.kagawa-u.ac.jp.
⁹ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: kenfact@med.kagawa-u.ac.jp.
¹⁰ Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: hagiike@med.kagawa-u.ac.jp.
¹¹ Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center, Tokyo, 190-0014, Japan. Electronic address: koido@outlook.jp.
¹² Kagawa University Hospital, Emergency Medical Center, Kita, Kagawa, 761-0793, Japan. Electronic address: kuroday@kms.ac.jp.

PMID: 25636520
DOI: 10.1016/j.ajem.2015.01.002

Abstract

The American Heart Association/American College of Cardiology Foundation recommends vitamin K1 for warfarin-related coagulopathy. In Japan, vitamin K2 is used more commonly for such purpose. The difference between vitamins K1 and K2 in reversing warfarin-related coagulopathy has not been discussed. Herein, we report a case that was reversed with vitamin K2; alterations in vitamins K1 and K2 levels and coagulation markers are also presented.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Anticoagulants / adverse effects*
Antifibrinolytic Agents / therapeutic use*
Arm / blood supply*
Blood Coagulation Disorders / chemically induced
Blood Coagulation Disorders / drug therapy*
Female
Hematoma / diagnostic imaging*
Hematoma / etiology
Humans
Radiography
Thoracic Wall / blood supply*
Vitamin K 2 / therapeutic use*
Warfarin / adverse effects*

Substances

Anticoagulants
Antifibrinolytic Agents
Vitamin K 2
Warfarin