Does transcription play a role in creating a condensin binding site?

Transcription. 2015;6(1):12-6. doi: 10.1080/21541264.2015.1012980. Epub 2015 Jan 29.

Abstract

The highly conserved condensin complex is essential for the condensation and integrity of chromosomes through cell division. Published data argue that high levels of transcription contribute to specify some condensin-binding sites on chromosomes but the exact role of transcription in this process remains elusive. Here we discuss our recent data addressing the role of transcription in establishing a condensin-binding site.

Keywords: CPF; R-Loops; Sen1; condensin; topological stress; transcription.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Binding Sites
  • Chromosomes, Human / metabolism
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Multiprotein Complexes / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Multiprotein Complexes
  • Saccharomyces cerevisiae Proteins
  • condensin complexes
  • Adenosine Triphosphatases