Abstract
An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemical synthesis*
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Alcohols / chemistry
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Aldehydes / chemistry*
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Amines / chemistry*
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Carboxylic Acids / chemistry*
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Catalysis
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Cyclization
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Lactones / chemical synthesis*
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Lactones / chemistry
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Molecular Structure
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Stereoisomerism
Substances
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Alcohols
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Aldehydes
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Amines
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Carboxylic Acids
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Lactones