Abstract
A series of N-monosubstituted and N,N'-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It has been found that indolo[3,2-b]carbazoles bearing basic N-alkyl substituents are intercalators that bind DNA with affinities in the micromolar and submicromolar range and a preference for associating with sequences of mixed composition and purine-pyrimidine steps.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Carbazoles / chemistry*
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Cattle
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DNA / chemistry*
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Hot Temperature
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Hydrogen-Ion Concentration
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Indoles / chemistry*
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Intercalating Agents / chemistry
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Kinetics
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Ligands
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Models, Chemical
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Organic Chemicals
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Permeability
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Protein Binding
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Purines / chemistry
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Pyridines / chemistry
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Spectrometry, Fluorescence
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Spectrophotometry, Ultraviolet
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Temperature
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Thymus Gland / metabolism
Substances
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Carbazoles
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Indoles
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Intercalating Agents
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Ligands
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Organic Chemicals
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Purines
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Pyridines
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DNA