Raman imaging of drug delivery systems

Geoffrey P S Smith; Cushla M McGoverin; Sara J Fraser; Keith C Gordon

doi:10.1016/j.addr.2015.01.005

Raman imaging of drug delivery systems

Adv Drug Deliv Rev. 2015 Jul 15:89:21-41. doi: 10.1016/j.addr.2015.01.005. Epub 2015 Jan 26.

Authors

Geoffrey P S Smith¹, Cushla M McGoverin², Sara J Fraser¹, Keith C Gordon³

Affiliations

¹ MacDiarmid Institute for Advanced Materials and Nanotechnology, Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin, New Zealand.
² Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Physics, University of Auckland, New Zealand.
³ MacDiarmid Institute for Advanced Materials and Nanotechnology, Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin, New Zealand. Electronic address: keith.gordon@otago.ac.nz.

PMID: 25632843
DOI: 10.1016/j.addr.2015.01.005

Abstract

This review article includes an introduction to the principals of Raman spectroscopy, an outline of the experimental systems used for Raman imaging and the associated important considerations and limitations of this method. Common spectral analysis methods are briefly described and examples of interesting published studies which utilised Raman imaging of pharmaceutical and biomedical devices are discussed, along with summary tables of the literature at this point in time.

Keywords: Chemometrics; Drug delivery; Drug dissolution; Multivariate methods; Polymeric microparticles; Pre-processing; Raman imaging; Solid dispersions.

Publication types

Review

MeSH terms

Drug Delivery Systems*
Drug Design
Humans
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / chemistry*
Spectrum Analysis, Raman / methods*

Substances

Pharmaceutical Preparations