Gold nanorod-photosensitizer complex obtained by layer-by-layer method for photodynamic/photothermal therapy in vitro

Seung Beom Kim; Tae Heon Lee; Il Yoon; Young Key Shim; Woo Kyoung Lee

doi:10.1002/asia.201403193

Gold nanorod-photosensitizer complex obtained by layer-by-layer method for photodynamic/photothermal therapy in vitro

Chem Asian J. 2015 Mar;10(3):563-7. doi: 10.1002/asia.201403193. Epub 2015 Jan 28.

Authors

Seung Beom Kim¹, Tae Heon Lee, Il Yoon, Young Key Shim, Woo Kyoung Lee

Affiliation

¹ Photodynamic Therapy Institute and School of Nano System Engineering, Inje University, 197 Injero, Gimhae, Gyeongnam 621-749 (Republic of Korea).

PMID: 25630881
DOI: 10.1002/asia.201403193

Abstract

Gold nanorod (GNR)-photosensitizer (PS) complex was prepared using anionic PS (sodium salt of purpurin-18) and cationic poly(allylamine hydrochloride) by layer-by-layer method, and was characterized by transmission electron microscopy, UV-vis spectroscopy, and zeta potential. The GNR-PS complex is a promising agent for synergistic (photothermal and photodynamic) therapy (PTT/PDT), in which PTT generates heat as well as operates the PS release which maximize the following PDT activity. The combined dual therapy, PTT followed by PDT, exhibits a significantly higher photocytotoxicity result based on synergistic effect of hyperthermia from PTT as well as singlet oxygen photogeneration from PDT.

Keywords: drug delivery; drug release; gold nanorods; photodynamic therapy; photothermal therapy; synergistic therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gold / chemistry*
Hot Temperature
Metal Nanoparticles / chemistry*
Photochemotherapy*
Photosensitizing Agents / chemistry*

Substances

Photosensitizing Agents
Gold