Pancreatic juice prostaglandin e2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Barham K Abu Dayyeh; Darwin Conwell; Navtej S Buttar; Vivek Kadilaya; Philip A Hart; Nikola A Baumann; Benjamin L Bick; Suresh T Chari; Sonia Chowdhary; Jonathan E Clain; Ferga C Gleeson; Linda S Lee; Michael J Levy; Randall K Pearson; Bret T Petersen; Elizabeth Rajan; Hanno Steen; Shadeah Suleiman; Peter A Banks; Santhi S Vege; Mark Topazian

doi:10.1038/ctg.2014.23

Pancreatic juice prostaglandin e2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Clin Transl Gastroenterol. 2015 Jan 29;6(1):e72. doi: 10.1038/ctg.2014.23.

Authors

Barham K Abu Dayyeh¹, Darwin Conwell², Navtej S Buttar¹, Vivek Kadilaya², Philip A Hart¹, Nikola A Baumann³, Benjamin L Bick¹, Suresh T Chari¹, Sonia Chowdhary¹, Jonathan E Clain¹, Ferga C Gleeson¹, Linda S Lee², Michael J Levy¹, Randall K Pearson¹, Bret T Petersen¹, Elizabeth Rajan¹, Hanno Steen⁴, Shadeah Suleiman², Peter A Banks², Santhi S Vege¹, Mark Topazian¹

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
² The Center for Pancreatic Disease, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Pathology and Proteomics Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease.

Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants.

Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations.

Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.