Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications

Samantha F Friend; Francina Deason-Towne; Lisa K Peterson; Allison J Berger; Leonard L Dragone

Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications

Am J Clin Exp Immunol. 2014 Dec 5;3(3):107-23. eCollection 2014.

Authors

Samantha F Friend¹, Francina Deason-Towne², Lisa K Peterson¹, Allison J Berger³, Leonard L Dragone⁴

Affiliations

¹ Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, CO 80206, USA.
² Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Department of Biology, Regis University Denver, CO 80221, USA.
³ Takeda Pharmaceuticals International Co. Cambridge, MA 02139, USA.
⁴ Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, CO 80206, USA ; Division of Rheumatology, Colorado Children's Hospital Aurora, CO 80045, USA ; Since completing this study, Dr. Dragone has joined Genentech, a member of the Roche group. Genentech South San Francisco, CA 94090, USA.

PMID: 25628960
PMCID: PMC4299764

Abstract

Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.

Keywords: MLN4924; NEDD8; SLAP; SUMO; T cell; c-Cbl; ubiquitin.

Publication types

Review

Abstract

Publication types

Grants and funding