Tyrosine phosphorylation of WW proteins

Abstract

A number of key regulatory proteins contain one or two copies of the WW domain known to mediate protein-protein interaction via proline-rich motifs, such as PPxY. The Hippo pathway components take advantage of this module to transduce tumor suppressor signaling. It is becoming evident that tyrosine phosphorylation is a critical regulator of the WW proteins. Here, we review the current knowledge on the involved tyrosine kinases and their roles in regulating the WW proteins.

Keywords: Hippo pathway; cell fate decision-making; non-receptor tyrosine kinases; protein tyrosine phosphorylation; protein–protein interaction.