The purpose of the study undertaken was to define the vulnerable fraction of the industrial population in northern Italy using the CHD risk score profile. In addition, ECG examinations were carried out in order to see whether there is a correlation between cardiovascular risk profile and the frequency of ECG abnormalities. The study covered in total 1443 male workers employed in various petrochemical plants. The calculation of the CHD risk score was based on age, relative weight, serum cholesterol, systolic blood pressure, smoking habit, physical activity at work and at home, and heredity factors. The study demonstrated that on an average 47.3% of male workers in the petrochemical industry have high or very high risk of cardiovascular disease and this draws the attention to the urgent need to develop the better and more effective primary preventive strategy against cardiovascular diseases, specially among manual workers. The study disclosed also that the persons with elevated risk score displayed more frequently ECG repolarization disorders.