Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

Jian Huo; Jiachuan Liu; Jinbiao Wang; Yongming Zhang; Chunlin Wang; Yanyan Yang; Wenjiang Sun; Shaonian Xu

doi:10.3969/j.issn.1673-5374.2012.22.008

Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

Neural Regen Res. 2012 Aug 5;7(22):1729-35. doi: 10.3969/j.issn.1673-5374.2012.22.008.

Authors

Jian Huo¹, Jiachuan Liu¹, Jinbiao Wang¹, Yongming Zhang¹, Chunlin Wang¹, Yanyan Yang¹, Wenjiang Sun¹, Shaonian Xu¹

Affiliation

¹ Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.

PMID: 25624795
PMCID: PMC4302454
DOI: 10.3969/j.issn.1673-5374.2012.22.008

Abstract

In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

Keywords: adrenocorticotropic hormone; aquaporin 4; blast-induced injury; craniocerebral injury; hyperbaric oxygen; pituitary gland.