Urinary phthalate metabolites are associated with insulin resistance in obese subjects

Environ Res. 2015 Feb:137:419-23. doi: 10.1016/j.envres.2015.01.010. Epub 2015 Jan 23.

Abstract

Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance.

Keywords: Beta-cell function; Diabetes; Insulin resistance; Obesity; Oral glucose tolerance test; Phthalates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Belgium
  • Blood Glucose / metabolism*
  • Cohort Studies
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Obesity / etiology
  • Obesity / physiopathology*
  • Overweight / etiology
  • Overweight / physiopathology*
  • Phthalic Acids / urine*
  • Young Adult

Substances

  • Blood Glucose
  • Phthalic Acids