Selective Efficacy of Temsirolimus on Bone Metastases in Chromophobe Renal Cell Carcinoma

Clin Genitourin Cancer. 2015 Aug;13(4):e321-e323. doi: 10.1016/j.clgc.2014.12.007. Epub 2014 Dec 20.
No abstract available

Keywords: Bone remodeling; Everolimus; Mammalian target of rapamycin (mTOR); Osteoclasts; Tuberous Sclerosis Complex 1 (TSC1).

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / secondary
  • Carcinoma, Renal Cell / drug therapy*
  • Carcinoma, Renal Cell / pathology
  • Disease Progression
  • Humans
  • Kidney Neoplasms / drug therapy*
  • Kidney Neoplasms / pathology
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / antagonists & inhibitors
  • Protein Kinase Inhibitors / administration & dosage*
  • Protein Kinase Inhibitors / therapeutic use
  • Sirolimus / administration & dosage
  • Sirolimus / analogs & derivatives*
  • Sirolimus / therapeutic use
  • TOR Serine-Threonine Kinases / antagonists & inhibitors
  • Treatment Outcome

Substances

  • Multiprotein Complexes
  • Protein Kinase Inhibitors
  • temsirolimus
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Sirolimus