[Treatment of spasticity in children with cerebral palsy with botulinum toxin A]

Ugeskr Laeger. 2015 Jan 12;177(3):V07140409.
[Article in Danish]

Abstract

Over the latest 30 years there has been an increasing use of botulinum toxin A injections in the lower limbs in children with cerebral palsy. However, the conclusions regarding effect of treatment in both randomized controlled and non-controlled trials have been inconclusive. One explanation may be that children with cerebral palsy do not always exhibit pure spasticity and/or dystonia of the affected muscles. Furthermore, the dose, injection volume and injection technique may vary from study to study. The evidence for the effect is so small that careful consideration on whether to continue this treatment regimen or not is needed.

Publication types

  • Review

MeSH terms

  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / therapeutic use*
  • Cerebral Palsy / complications
  • Cerebral Palsy / diagnostic imaging
  • Cerebral Palsy / drug therapy*
  • Child
  • Denmark
  • Evidence-Based Medicine
  • Humans
  • Injections, Intramuscular
  • Leg
  • Muscle Spasticity / diagnostic imaging
  • Muscle Spasticity / drug therapy*
  • Muscle Spasticity / etiology
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / therapeutic use*

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A