Abstract
The antiproliferative potential of a crude extract from the chayote hybrid H-837-07-GISeM® and its potential for apoptosis induction were assessed in leukaemic cell lines and normal mouse bone marrow mononuclear cells (BM-MNCs). The extract strongly inhibited the proliferation of the P388, J774, and WEHI-3 cell lines (with an IC50 below 1.3 μg·mL(-1)), reduced cell viability, and induced apoptotic body production, phosphatidylserine translocation, and DNA fragmentation. However, the extract had no effect on BM-MNCs. We postulate that these properties make the extract a good candidate for an anti-tumour agent for clinical use.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects*
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Bone Marrow Cells / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chimera
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Cucurbitaceae* / chemistry
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DNA Fragmentation
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Female
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Fruit*
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Leukemia / drug therapy*
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Leukemia / pathology
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Leukemia P388 / drug therapy
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Leukemia P388 / pathology
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Mice
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Monocytes / drug effects
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Phospholipid Transfer Proteins / drug effects
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Plant Extracts / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Phospholipid Transfer Proteins
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Plant Extracts