Abstract
Three new citrinin analogues, penicitols A-C (1-3), and one new xanthone derivative, penixanacid A (4), together with four known biogenetically related compounds (5-8), were discovered from the extract of a mangrove-derived fungus, Penicillium chrysogenum HND11-24. The structures of penicitols A-C and penixanacid A were established through analysis of extensive spectroscopic data. Their cytotoxic activity against HeLa, BEL-7402, HEK-293, HCT-116, and A549 cell lines was evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents* / pharmacology
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China
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Citrinin* / analogs & derivatives
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Citrinin* / chemistry
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Citrinin* / isolation & purification
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Citrinin* / pharmacology
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Drug Screening Assays, Antitumor
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HCT116 Cells
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HEK293 Cells
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HeLa Cells
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Humans
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Molecular Structure
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Mycotoxins* / chemistry
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Mycotoxins* / isolation & purification
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Mycotoxins* / pharmacology
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Penicillium chrysogenum / chemistry*
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Rhizophoraceae / microbiology*
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Xanthones* / chemistry
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Xanthones* / isolation & purification
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Xanthones* / pharmacology
Substances
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Antineoplastic Agents
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Mycotoxins
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Xanthones
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penicitol A
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penicitol B
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penicitol C
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penixanacid A
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Citrinin