Bugs, guts, and glia: how microbiota influence enteric gliogenesis and migration

Meenakshi Rao; Michael D Gershon

doi:10.1016/j.neuron.2014.12.066

Bugs, guts, and glia: how microbiota influence enteric gliogenesis and migration

Neuron. 2015 Jan 21;85(2):229-30. doi: 10.1016/j.neuron.2014.12.066.

Authors

Meenakshi Rao¹, Michael D Gershon²

Affiliations

¹ Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: mr3343@cumc.columbia.edu.
² Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: mdg4@cumc.columbia.edu.

Abstract

Enteric glia are neural crest derivatives. Kabouridis et al. (2015) now show in adult animals that new glia arise within the ganglia of enteric plexuses and then migrate centripetally to colonize the mucosa. Remarkably, enteric microbiota regulate this critical migration.

Publication types

Comment

MeSH terms

Animals
Homeostasis / physiology*
Intestinal Mucosa / cytology*
Intestines / microbiology*
Microbiota / physiology*
Neuroglia / physiology*
Submucous Plexus / cytology*

Grants and funding

R01 NS015547/NS/NINDS NIH HHS/United States