Abstract
Phytochemical investigation of an extract of the aerial part of Barleria lupulina resulted in the identification of four new iridoid glycosides (1-4), together with 14 known analogues (5-18). The structures of 1-4 were determined through 1D and 2D NMR spectroscopic data analysis, HRMS, and acid hydrolysis. This is the first report of iridoid glycosides with a formate group. The free-radical scavenging activity of compounds 9, 12, and 15-17 was assessed using the DPPH assay. Compounds 16 and 17 scavenged DPPH radicals weakly with IC50 values of 97.5 and 78.6 μg/mL, respectively.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acanthaceae / chemistry*
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Biphenyl Compounds / pharmacology
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Inhibitory Concentration 50
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Iridoid Glycosides / chemistry
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Iridoid Glycosides / isolation & purification*
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Iridoid Glycosides / pharmacology
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Molecular Structure
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Picrates / pharmacology
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Vietnam
Substances
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Biphenyl Compounds
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Free Radical Scavengers
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Iridoid Glycosides
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Picrates
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Plant Extracts
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1,1-diphenyl-2-picrylhydrazyl