Abstract
CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Atherosclerosis / immunology
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Atherosclerosis / metabolism*
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Atherosclerosis / pathology
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Basigin / immunology
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Basigin / metabolism*
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Blood Platelets / immunology
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Blood Platelets / metabolism
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Blood Vessels / immunology
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Blood Vessels / metabolism*
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Blood Vessels / pathology
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Humans
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Immune System / immunology
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Immune System / metabolism
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Oxidative Stress
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Plaque, Atherosclerotic
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Receptors, Cell Surface / metabolism
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Signal Transduction
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Thrombosis / immunology
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Thrombosis / metabolism*
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Thrombosis / pathology
Substances
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Receptors, Cell Surface
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Basigin