A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis - a case of virally induced periodontitis?

J Clin Virol. 2015 Feb:63:46-50. doi: 10.1016/j.jcv.2014.12.003. Epub 2014 Dec 5.

Abstract

We present a 17-year old girl with DOCK-8 deficiency, severe untreated oral HSV-1 infection and associated aggressive periodontitis. DOCK-8 deficiency is a primary immunodeficiency, caused by biallelicloss-of-function mutations in the DOCK8 gene, often leading to severe viral and fungal mucocutaneous infections. Nevertheless, to date DOCK8 has not been associated with severe periodontitis and inflammatory bone loss around teeth. Understanding whether DOCK8 deficiency or severe HSV-1 infection underlies susceptibility to periodontitis is central to this case and may provide insights into susceptibility factors for periodontitis in the general population. Our clinical and microbiological data suggest that severe HSV-1 infection is the driver of periodontal inflammation in this case.

Keywords: Aggressive periodontitis; DOCK8 deficiency; Oral HSV-1.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adolescent
  • Aggressive Periodontitis / pathology*
  • Aggressive Periodontitis / virology*
  • Disease Susceptibility
  • Female
  • Guanine Nucleotide Exchange Factors / deficiency*
  • Herpes Simplex / complications*
  • Herpes Simplex / diagnosis*
  • Herpes Simplex / pathology
  • Herpesvirus 1, Human / isolation & purification*
  • Humans

Substances

  • DOCK8 protein, human
  • Guanine Nucleotide Exchange Factors