Abstract
The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adiposity
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Animals
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Anti-Obesity Agents / analysis
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / isolation & purification
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Anti-Obesity Agents / therapeutic use*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / etiology
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / prevention & control
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Diet, High-Fat / adverse effects
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Dietary Supplements* / analysis
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Glycated Hemoglobin / analysis
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Glycine max / chemistry*
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Glycine max / growth & development
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Glycosides / analysis
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / therapeutic use
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Humans
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Hypertriglyceridemia / complications
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Hypertriglyceridemia / etiology
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Hypertriglyceridemia / metabolism
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Hypertriglyceridemia / prevention & control
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Hypoglycemic Agents / analysis
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / therapeutic use*
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Hypolipidemic Agents / analysis
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / isolation & purification
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Hypolipidemic Agents / therapeutic use
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Insulin Resistance
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Kaempferols / analysis
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Kaempferols / chemistry
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Kaempferols / isolation & purification
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Kaempferols / therapeutic use*
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Lipid Metabolism
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Male
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Mice, Inbred C57BL
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Obesity / complications
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Obesity / etiology
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Obesity / metabolism
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Obesity / prevention & control*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / therapeutic use
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Plant Leaves / chemistry*
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Plant Leaves / growth & development
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Random Allocation
Substances
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Anti-Obesity Agents
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Glycated Hemoglobin A
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Glycosides
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Hypoglycemic Agents
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Hypolipidemic Agents
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Kaempferols
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Plant Extracts
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kaempferol