A pain in the NEC: research challenges and opportunities

J Pediatr Surg. 2015 Jan;50(1):23-9. doi: 10.1016/j.jpedsurg.2014.10.024. Epub 2014 Nov 7.

Abstract

This lecture will describe how the properties of heparin-binding EFG-like growth factor (HB-EGF) can be utilized to protect the intestines from necrotizing enterocolitis (NEC), to augment the effects of stem cells in the treatment of NEC, and to improve the production of tissue-engineered intestine. It will also explore the role of the enteric nervous system in the development of NEC.

Keywords: HB-EGF; Intestine; Necrotizing enterocolitis; Tissue engineering.

Publication types

  • Lecture
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Enterocolitis, Necrotizing / prevention & control
  • Enterocolitis, Necrotizing / therapy*
  • Heparin-binding EGF-like Growth Factor / pharmacology
  • Heparin-binding EGF-like Growth Factor / therapeutic use*
  • Humans
  • Intestines / cytology
  • Intestines / drug effects*
  • Protective Agents / therapeutic use*
  • Rats
  • Research
  • Stem Cells / drug effects*
  • Tissue Engineering

Substances

  • Heparin-binding EGF-like Growth Factor
  • Protective Agents