Japan Clinical Oncology Group (JCOG) is a largest cooperative group in Japan, funded by the ministry of health, labor and welfare of Japanese government. We just established the Geriatric Study Committee in December 2013. The goal of this committee is to make a policy to promote clinical trials for older patients with 3 major tasks: (1) Create a clear and operational definition of vulnerability/frailty applicable to oncology,(2)Develop, test and disseminate geriatric assessments, (3) Improve research in the field of geriatric oncology, in collaboration with SIOG. JCOG1018 is a randomized phase III study of mFOLFOX7 or CAPOX plus bevacizumab versus 5-fluorouracil/Leucovorin or capecitabine plus bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer. This study includes geriatric assessments (VES-13) before chemotherapy.