Manipulating IL-10 signalling blockade for better immunotherapy

Guoying Ni; Tianfang Wang; Shelley Walton; Bin Zhu; Shu Chen; Xiaolian Wu; Yuejian Wang; Ming Q Wei; Xiaosong Liu

doi:10.1016/j.cellimm.2014.12.012

Manipulating IL-10 signalling blockade for better immunotherapy

Cell Immunol. 2015 Feb;293(2):126-9. doi: 10.1016/j.cellimm.2014.12.012. Epub 2015 Jan 8.

Authors

Guoying Ni¹, Tianfang Wang², Shelley Walton³, Bin Zhu⁴, Shu Chen⁴, Xiaolian Wu⁴, Yuejian Wang⁵, Ming Q Wei⁶, Xiaosong Liu⁷

Affiliations

¹ School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia.
² Genecology Research Centre, University of Sunshine Coast, Sippy Downs 4556, QLD, Australia.
³ Inflammation and Healing Research Cluster, University of Sunshine Coast, Sippy Downs 4556, Australia.
⁴ Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China.
⁵ Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China. Electronic address: yjwang@fsyyy.com.
⁶ School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia. Electronic address: m.wei@griffith.edu.au.
⁷ Inflammation and Healing Research Cluster, University of Sunshine Coast, Sippy Downs 4556, Australia; Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China. Electronic address: xiaosongl@yahoo.com.

PMID: 25596475
DOI: 10.1016/j.cellimm.2014.12.012

Abstract

Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels of interleukin 10 in peripheral blood. Serum IL-10 levels are also high in certain cancers. Blocking IL-10 signalling at the time of immunisation clears chronic viral infection and prevents tumour growth in animal models. We review recent advances in this area, with the emphasis on potential use of this novel strategy to treat chronic viral infection and cancer in human.

Keywords: Immunotherapy; Interleukin 10; Vaccine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
HIV Infections / immunology*
HIV Infections / therapy
Hepatitis B, Chronic / immunology*
Hepatitis B, Chronic / therapy
Hepatitis C, Chronic / immunology*
Hepatitis C, Chronic / therapy
Humans
Immunotherapy
Interleukin-10 / immunology*
Signal Transduction / immunology*
T-Lymphocytes / immunology*
T-Lymphocytes / virology

Substances

Interleukin-10