A computerized framework for monitoring four-dimensional dose distributions during stereotactic body radiation therapy using a portal dose image-based 2D/3D registration approach

Takahiro Nakamoto; Hidetaka Arimura; Katsumasa Nakamura; Yoshiyuki Shioyama; Asumi Mizoguchi; Taka-Aki Hirose; Hiroshi Honda; Yoshiyuki Umezu; Yasuhiko Nakamura; Hideki Hirata

doi:10.1016/j.compmedimag.2014.12.003

A computerized framework for monitoring four-dimensional dose distributions during stereotactic body radiation therapy using a portal dose image-based 2D/3D registration approach

Comput Med Imaging Graph. 2015 Mar:40:1-12. doi: 10.1016/j.compmedimag.2014.12.003. Epub 2014 Dec 26.

Authors

Affiliations

¹ Division of Medical Quantum Science, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
² Division of Medical Quantum Science, Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: arimurah@med.kyushu-u.ac.jp.
³ Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
⁴ Saga Heavy Ion Medical Accelerator in Tosu, Saga, Japan.
⁵ Kurume University Hospital, Fukuoka, Japan.
⁶ Kyushu University Hospital, Fukuoka, Japan.
⁷ Division of Medical Quantum Science, Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

PMID: 25592290
DOI: 10.1016/j.compmedimag.2014.12.003

Abstract

A computerized framework for monitoring four-dimensional (4D) dose distributions during stereotactic body radiation therapy based on a portal dose image (PDI)-based 2D/3D registration approach has been proposed in this study. Using the PDI-based registration approach, simulated 4D "treatment" CT images were derived from the deformation of 3D planning CT images so that a 2D planning PDI could be similar to a 2D dynamic clinical PDI at a breathing phase. The planning PDI was calculated by applying a dose calculation algorithm (a pencil beam convolution algorithm) to the geometry of the planning CT image and a virtual water equivalent phantom. The dynamic clinical PDIs were estimated from electronic portal imaging device (EPID) dynamic images including breathing phase data obtained during a treatment. The parameters of the affine transformation matrix were optimized based on an objective function and a gamma pass rate using a Levenberg-Marquardt (LM) algorithm. The proposed framework was applied to the EPID dynamic images of ten lung cancer patients, which included 183 frames (mean: 18.3 per patient). The 4D dose distributions during the treatment time were successfully obtained by applying the dose calculation algorithm to the simulated 4D "treatment" CT images. The mean±standard deviation (SD) of the percentage errors between the prescribed dose and the estimated dose at an isocenter for all cases was 3.25±4.43%. The maximum error for the ten cases was 14.67% (prescribed dose: 1.50Gy, estimated dose: 1.72Gy), and the minimum error was 0.00%. The proposed framework could be feasible for monitoring the 4D dose distribution and dose errors within a patient's body during treatment.

Keywords: 2D/3D registration; Four-dimensional dose distribution; Optimization; Stereotactic body radiation therapy.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Algorithms
Female
Four-Dimensional Computed Tomography / methods*
Humans
Lung Neoplasms / diagnostic imaging
Lung Neoplasms / surgery*
Male
Middle Aged
Radiographic Image Interpretation, Computer-Assisted / methods*
Radiosurgery / methods*
Radiotherapy Dosage*
Radiotherapy, Image-Guided / methods*
Reproducibility of Results
Sensitivity and Specificity
Surgery, Computer-Assisted / methods
Whole-Body Counting / methods