ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety

Abstract

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport, an acute satiety factor, a regulator of gastric function, and, finally, a modulator of blood glucose homeostasis. The purpose of this review is to update our current view of intestinal apoA-IV synthesis and secretion and the physiological roles of apoA-IV in lipid metabolism and energy homeostasis, and to underscore the potential for intestinal apoA-IV to serve as a therapeutic target for the treatment of diabetes and obesity-related disease.

Keywords: apolipoprotein A-IV (apoA-IV); cardiovascular disease; chylomicron; diabetes; glucose homeostasis; intestinal lipid transport; lymph fistula mouse model; obesity; satiety.