Abstract
In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate and noncholinergic nerve stimulation were blocked following desensitization of P2X-purinoceptors by alpha,beta-methylene ATP. Thus, adenine dinucleotides can act on P2X-purinoceptors and there is an element of purinergic neuromuscular transmission in the human urinary bladder.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine Nucleotides / pharmacology*
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Adenosine Triphosphate / analogs & derivatives
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Adenosine Triphosphate / pharmacology
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Adult
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Aged
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Dinucleoside Phosphates / pharmacology
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Electric Stimulation
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Female
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Humans
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In Vitro Techniques
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Male
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Middle Aged
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Muscle, Smooth / drug effects*
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Neuromuscular Junction / drug effects
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Receptors, Purinergic / drug effects*
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Synaptic Transmission / drug effects
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Urinary Bladder / drug effects
Substances
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Adenine Nucleotides
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Dinucleoside Phosphates
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Receptors, Purinergic
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P(1),P(5)-di(adenosine-5'-)pentaphosphate
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Adenosine Triphosphate
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alpha,beta-methyleneadenosine 5'-triphosphate