Abstract
Type I collagen synthesis in osteoblasts is regulated by a variety of systemic hormones, growth factors and locally produced factors. With the use of cDNA probes and hybridization analysis, it appears that many of these agents alter collagen synthesis by a pretranslational mechanism.
MeSH terms
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Animals
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Cells, Cultured
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Cholecalciferol / pharmacology
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Cholecalciferol / physiology
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Collagen / genetics*
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Collagen / metabolism
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology*
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Insulin / pharmacology
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Insulin / physiology
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Insulin-Like Growth Factor I / pharmacology
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Insulin-Like Growth Factor I / physiology
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Osteoblasts / metabolism*
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Osteoblasts / physiology
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Parathyroid Hormone / pharmacology
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Parathyroid Hormone / physiology
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Rats
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Skull / cytology
Substances
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Insulin
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Parathyroid Hormone
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Cholecalciferol
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Insulin-Like Growth Factor I
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Collagen