Radiofrequency ablation of drug-resistant cancer cells using molecularly targeted carboxyl-functionalized biodegradable graphene

Adv Healthc Mater. 2015 Apr 2;4(5):679-84. doi: 10.1002/adhm.201400670. Epub 2015 Jan 13.

Abstract

Under ultralow radiofrequency (RF) power, transferrin-conjugated graphene nanoparticles can thermally ablate drug- or radiation-resistant cancer cells very effectively. The results suggest that graphene-based RF hyperthermia can be an efficient method to manage drug-/radiation-resistant cancers.

Keywords: cancer therapy; drug resistance; graphene; radiofrequency ablation; transferrin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology*
  • Catheter Ablation
  • Cell Line, Tumor
  • Cell Survival / drug effects*
  • Cell Survival / radiation effects*
  • Drug Resistance, Neoplasm
  • Graphite / chemistry
  • Graphite / pharmacology*
  • Humans
  • Microscopy, Confocal
  • Radio Waves*

Substances

  • Antineoplastic Agents
  • Biocompatible Materials
  • Graphite