A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids

Amino Acids. 2015 Apr;47(4):779-85. doi: 10.1007/s00726-014-1908-7. Epub 2015 Jan 13.

Abstract

The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Chemistry Techniques, Synthetic / methods*
  • Molecular Structure
  • Peptides / chemical synthesis
  • Peptides / chemistry

Substances

  • Amino Acids
  • Peptides