Chondroitin sulphate-guided construction of polypyrrole nanoarchitectures

Mater Sci Eng C Mater Biol Appl. 2015 Mar:48:172-8. doi: 10.1016/j.msec.2014.11.070. Epub 2014 Dec 2.

Abstract

Nanospheres, nanocones, and nanowires are three typical polypyrrole (PPy) nanoarchitectures and electrochemically polymerized with the dope of chondroitin sulphate (CS) in this study. CS, a functional biomacromolecule, guides the formation of PPy nanoarchitectures as the dopant and morphology-directing agent. Combined with our previous reported other PPy nanoarchitectures (such as nanotube arrays and nanowires), this work further proposed the novel mechanism of the construction of PPy/CS nanoarchitectures with the synergistic effect of CS molecular chains structure and the steric hindrance. Compared to the undoped PPy, MC3T3-E1 cells with PPy/CS nanoarchitectures possessed stronger proliferation and osteogenic differentiation capability. This suggests that PPy/CS nanoarchitectures have appropriate biocompatibility. Altogether, the nanoarchitectured PPy/CS may find application in the regeneration of bone defect.

Keywords: Chondroitin sulphate; Conducting polymers; Nanoarchitectures; Polypyrrole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Cell Line / drug effects
  • Cell Survival / drug effects
  • Chondroitin Sulfates / chemistry*
  • Chondroitin Sulfates / pharmacology
  • Female
  • Hemolysis / drug effects
  • Humans
  • Mice
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Osteogenesis / drug effects
  • Photoelectron Spectroscopy
  • Polymers / chemistry*
  • Polymers / pharmacology
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology
  • Surface Properties

Substances

  • Polymers
  • Pyrroles
  • polypyrrole
  • Chondroitin Sulfates