Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock

Biomarkers. 2015 Mar;20(2):132-5. doi: 10.3109/1354750X.2014.1000971. Epub 2015 Jan 12.

Abstract

Context: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk.

Objective: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT).

Methods: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235).

Results: The area under the curve for ASSIST was greater than that of IL6 and PCT.

Conclusions: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

Keywords: Biomarkers; decision tree; modeling; outcome; sepsis; stratification.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Cohort Studies
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Prognosis
  • Protein Precursors / blood*
  • ROC Curve
  • Reproducibility of Results
  • Risk Assessment / methods*
  • Risk Factors
  • Sepsis / blood*
  • Sepsis / diagnosis
  • Sepsis / mortality
  • Severity of Illness Index
  • Shock, Septic / blood*
  • Shock, Septic / diagnosis
  • Shock, Septic / mortality
  • Survival Analysis
  • Survival Rate

Substances

  • Biomarkers
  • CALCA protein, human
  • Interleukin-6
  • Protein Precursors
  • Calcitonin
  • Calcitonin Gene-Related Peptide