In search of human hematopoietic stem cell identity

Andrejs Ivanovs; Alexander Medvinsky

doi:10.1016/j.stem.2014.12.010

In search of human hematopoietic stem cell identity

Cell Stem Cell. 2015 Jan 8;16(1):5-6. doi: 10.1016/j.stem.2014.12.010.

Authors

Andrejs Ivanovs¹, Alexander Medvinsky²

Affiliations

¹ MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
² MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK. Electronic address: a.medvinsky@ed.ac.uk.

PMID: 25575075
DOI: 10.1016/j.stem.2014.12.010

Abstract

Better insight into hematopoietic stem cell (HSC) development in the human embryo and fetus is crucial for translational research. In this issue of Cell Stem Cell, Prashad et al. (2014) describe a novel surface marker for human fetal liver HSCs, glycosylphosphatidylinositol-anchored protein GPI-80, that is functionally required for their self-renewal.

Publication types

Comment

MeSH terms

Amidohydrolases / metabolism*
Cell Adhesion Molecules / metabolism*
Embryonic Development*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism*
Humans

Substances

Cell Adhesion Molecules
Amidohydrolases