Targeting the cellular origin of organ fibrosis

Johnny Kim; Thomas Braun

doi:10.1016/j.stem.2014.12.008

Targeting the cellular origin of organ fibrosis

Cell Stem Cell. 2015 Jan 8;16(1):3-4. doi: 10.1016/j.stem.2014.12.008.

Authors

Johnny Kim¹, Thomas Braun²

Affiliations

¹ Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
² Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: thomas.braun@mpi-bn.mpg.de.

PMID: 25575074
DOI: 10.1016/j.stem.2014.12.008

Abstract

Organ fibrosis after injury, which can significantly compromise tissue function, is in part due to proliferation of fibroblasts and myofibroblasts of unclear cellular origin. Now in Cell Stem Cell, Kramann et al. (2015) show that perivascular Gli1+ mesenchymal-stem-cell-like cells generate a large fraction of myofibroblasts in disease conditions.

Publication types

Comment

MeSH terms

Animals
Fibrosis / pathology*
Humans
Kruppel-Like Transcription Factors / metabolism*

Substances

Kruppel-Like Transcription Factors