Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers

L M Cranmer; M Kanyugo; B Lohman-Payne; K Tapia; G C John-Stewart

doi:10.5588/ijtld.14.0384

Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers

Int J Tuberc Lung Dis. 2015 Feb;19(2):141-3. doi: 10.5588/ijtld.14.0384.

Authors

L M Cranmer¹, M Kanyugo², B Lohman-Payne³, K Tapia⁴, G C John-Stewart⁵

Affiliations

¹ Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA; Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
² Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
³ Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya; Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA.
⁴ Department of Biostatistics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA.
⁵ Department of Pediatrics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Abstract

Tuberculosis (TB) cellular immune responses were examined in the breast milk of human immunodeficiency virus infected mothers using the T-SPOT. TB interferon-gamma release assay (IGRA). Positive TB interferon-gamma (IFN-γ) responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breast milk and blood assays, TB IFN-γ responses were higher in breast milk than in blood (P = 0.02). The magnitude of TB IFN-γ responses in maternal breast milk and blood were correlated. Elucidating the influence of TB immune responses in breast milk on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Female
HIV Infections / immunology*
Humans
Immunity, Cellular
Infant
Infant, Newborn
Interferon-gamma / immunology*
Interferon-gamma Release Tests
Milk, Human / immunology*
Tuberculosis / immunology*

Substances

Interferon-gamma

Abstract

Publication types

MeSH terms

Substances

Grants and funding