Toxin effect on protein biosynthesis in eukaryotic cells: a simple kinetic model

Math Biosci. 2015 Mar:261:83-90. doi: 10.1016/j.mbs.2014.12.004. Epub 2015 Jan 5.

Abstract

A model for toxin inhibition of protein synthesis inside eukaryotic cells is presented. Mitigation of this effect by introduction of an antibody is also studied. Antibody and toxin (ricin) initially are delivered outside the cell. The model describes toxin internalization from the extracellular into the intracellular domain, its transport to the endoplasmic reticulum (ER) and the cleavage inside the ER into the RTA and RTB chains, the release of RTA into the cytosol, inactivation (depurination) of ribosomes, and the effect on translation. The model consists of a set of ODEs which are solved numerically. Numerical results are illustrated by figures and discussed.

Keywords: Antibody; Cell receptor; Protein biosynthesis; Ricin; Toxin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / administration & dosage
  • Endoplasmic Reticulum / metabolism
  • Eukaryotic Cells
  • Humans
  • Kinetics
  • Mathematical Concepts
  • Models, Biological
  • Protein Biosynthesis / drug effects*
  • Ricin / immunology
  • Ricin / pharmacokinetics
  • Ricin / toxicity
  • Toxins, Biological / immunology
  • Toxins, Biological / pharmacokinetics
  • Toxins, Biological / toxicity*

Substances

  • Antibodies
  • Toxins, Biological
  • Ricin