Recent studies have been showed as the perception of real or displayed masterpieces by ancient or modern painters generate stable neuroelectrical correlates in humans. In this study, we collected the neuroelectrical brain activity correlated with the observation of the real sculpture of Michelangelo's Moses within the church where it is actually installed in a group of healthy subjects. In addition to the cerebral activity also the heart rate (HR) and the galvanic skin response (GSR) were collected simultaneously, to assess the emotional engage of the investigated population. The Moses sculpture was observed by the group from three different point of views, each one revealing different details of the sculpture. In addition, in each location the light conditions related to the specific observation of the sculpture were explicitly changed. Results showed that cerebral activity of the subjects varied significantly across the three different views and for light condition against no light condition (p<;0.04). Furthermore, the emotional engage estimated on the whole population is higher for a point of observation in which the Mose's face is directed toward the eyes of the observers (p<;0.02). Finally, the cerebral appreciation of the investigated group was found maximum from a perspective in which all the details of the sculpture could be easily grab by the eyes. Results suggested how the perception of the sculpture depends critically by the point of view of the observers and how such point of view can produce separate emotional and cerebral responses.