Abstract
Calcium phosphate cements (CPCs) with osteoconductive properties are limited in their applications because of their poor mechanical properties. This study investigated the additive effect of Dexamethasone-doped Halloysite Nanotubes (HNTs on the mechanical properties of CPCs. HNTs are nanosized tubes with alumino-silicate composition. Physico-chemical properties, cytocompatability and cellular functionality of the nanocomposites were assayed. Results suggest that these nanoenhanced composites have a huge potential to broaden the applications of CPCs.
MeSH terms
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Alkaline Phosphatase / analysis
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Aluminum Silicates / chemistry*
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Animals
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Bone Cements / chemistry*
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Bone Marrow Cells / cytology
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Calcium Phosphates / chemistry*
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Cell Line
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Clay
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Collagen / analysis
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Dexamethasone / chemistry
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Dexamethasone / pharmacology
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Glycosaminoglycans / analysis
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / drug effects
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Mesenchymal Stem Cells / metabolism
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Mice
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Microscopy, Electron, Scanning
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Nanoparticles / chemistry*
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Nanotubes / chemistry
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Particle Size
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Spectroscopy, Fourier Transform Infrared
Substances
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Aluminum Silicates
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Bone Cements
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Calcium Phosphates
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Glycosaminoglycans
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Dexamethasone
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Collagen
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calcium phosphate
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Alkaline Phosphatase
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Clay