An implantable, miniaturized SU-8 optical probe for optogenetics-based deep brain stimulation

Annu Int Conf IEEE Eng Med Biol Soc. 2014:2014:450-3. doi: 10.1109/EMBC.2014.6943625.

Abstract

This paper reports a method of making optical probes for optogenetics-based deep brain optical stimulation using SU-8, which effectively increases light coupling efficiency, has excellent mechanical stiffness, and reduces fabrication complexity. By mounting microscale LEDs (μLEDs) at the tip of a SU-8 probe and directly inserting the light source into deep brain regions, attenuation caused by light transmission in wave-guided structures such as optical fibers or optrodes can be minimized. Compared to silicon neural probes, SU-8 is more biocompatible and flexible, which can reduce brain damage. Parylene-C encapsulation can potentially improve the long-term biocompatibility and reliability of the device for chronic implantation. The functionality has been proven by clearly light-induced neural activity.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Deep Brain Stimulation / instrumentation*
  • Epoxy Compounds*
  • Optogenetics / instrumentation*
  • Polymers*
  • Prostheses and Implants*

Substances

  • Epoxy Compounds
  • Polymers
  • SU-8 compound