Abstract
Here we report in a human, a renal transplant patient, the first disseminated infection with Nocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA, gyrB, and hsp65 gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / therapeutic use
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Anti-Bacterial Agents / therapeutic use
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Brain / microbiology
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Brain / pathology
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Carbapenems / therapeutic use
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Cluster Analysis
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DNA Gyrase
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Female
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Heat-Shock Proteins
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Humans
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Kidney Transplantation
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Microbial Sensitivity Tests
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Microscopy
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Middle Aged
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Molecular Sequence Data
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Nocardia / chemistry
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Nocardia / classification*
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Nocardia / genetics
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Nocardia / isolation & purification*
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Nocardia Infections / diagnosis*
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Nocardia Infections / microbiology
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Phylogeny
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RNA, Ribosomal, 16S / genetics
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Radiography, Abdominal
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Radiography, Thoracic
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Sepsis / diagnosis*
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Sepsis / microbiology
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Sequence Analysis, DNA
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Transplant Recipients
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Treatment Outcome
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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DNA, Ribosomal
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Heat-Shock Proteins
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RNA, Ribosomal, 16S
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Trimethoprim, Sulfamethoxazole Drug Combination
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DNA Gyrase
Associated data
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GENBANK/KP013615
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GENBANK/KP013616
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GENBANK/KP013617