NOTA: a potent metallo-β-lactamase inhibitor

J Antimicrob Chemother. 2015 May;70(5):1594-6. doi: 10.1093/jac/dku538. Epub 2015 Jan 6.
No abstract available

Keywords: DOTA; MBLs; carbapenemases; metal-chelating agents.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Heterocyclic Compounds / pharmacology*
  • Heterocyclic Compounds, 1-Ring / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • beta-Lactam Resistance / drug effects*
  • beta-Lactamase Inhibitors / pharmacology*
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • beta-Lactamase Inhibitors
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid
  • beta-Lactamases