Abstract
The first enantioselective total synthesis of (-)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Biological Products / pharmacology
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Catalysis
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Copper
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Cyclization
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Gold
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Molecular Structure
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Oxidation-Reduction
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology
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Stereoisomerism
Substances
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Biological Products
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Sesquiterpenes
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nardoaristolone B
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Gold
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Copper