Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism

Org Lett. 2015 Jan 16;17(2):262-5. doi: 10.1021/ol503349y. Epub 2015 Jan 5.

Abstract

Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Cell Line
  • Furans / chemistry*
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects*
  • Histone Deacetylase Inhibitors / metabolism
  • Histone Deacetylase Inhibitors / pharmacology
  • Humans
  • Molecular Structure
  • Polyketides / chemistry*
  • Protein Kinase C / chemistry*
  • Protein Kinase C / metabolism
  • Protein Kinase C / pharmacology
  • Virus Latency / drug effects*

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Furans
  • Histone Deacetylase Inhibitors
  • Polyketides
  • abyssomicin C
  • Protein Kinase C
  • tetronic acid