Abstract
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Cell Line
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Furans / chemistry*
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HIV Infections / drug therapy*
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HIV-1 / drug effects*
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Histone Deacetylase Inhibitors / metabolism
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Histone Deacetylase Inhibitors / pharmacology
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Humans
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Molecular Structure
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Polyketides / chemistry*
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Protein Kinase C / chemistry*
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Protein Kinase C / metabolism
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Protein Kinase C / pharmacology
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Virus Latency / drug effects*
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Furans
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Histone Deacetylase Inhibitors
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Polyketides
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abyssomicin C
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Protein Kinase C
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tetronic acid