Abstract
The nucleoid-associated protein H-NS silences unwanted expression of acquired foreign DNA. Ali and colleagues recently identified which horizontally-acquired genes are targeted by H-NS in Salmonella to avoid fitness loss. The reported data strengthen our view about the role of H-NS in bacterial evolution driven by horizontal gene transfer.
Keywords:
H-NS; HGT; SPI1; Salmonella; StpA.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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DNA-Binding Proteins / genetics*
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Enterobacteriaceae / genetics
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Escherichia coli Proteins / genetics
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Evolution, Molecular*
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Gene Silencing*
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Gene Transfer, Horizontal*
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Genetic Fitness
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Molecular Chaperones / genetics
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Salmonella / genetics*
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Escherichia coli Proteins
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H-NS protein, bacteria
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Molecular Chaperones
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StpA protein, E coli
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StpA protein, Salmonella typhimurium