Hierarchical construction of a mechanically stable peptide-graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo

Nanoscale. 2015 Feb 7;7(5):1655-60. doi: 10.1039/c4nr05798h.

Abstract

The design of hydrogels with controllable drug-release properties remains challenging. Here we report a hydrogel made of hierarchical graphene oxide sheets and peptide assemblies for on-demand drug release. The hydrogel possesses high drug-sustainability and the release of drugs can be precisely and remotely controlled through external stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Bombyx / metabolism
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers / chemistry*
  • Graphite / chemistry*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Mice
  • Mice, Nude
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Oxides / chemistry
  • Peptides / chemistry*
  • Protein Structure, Secondary
  • Silk / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Transplantation, Heterologous

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Oxides
  • Peptides
  • Silk
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Graphite
  • Doxorubicin