Host-pathogen interactions during porcine reproductive and respiratory syndrome virus 1 infection of piglets

Virus Res. 2015 Apr 16:202:135-43. doi: 10.1016/j.virusres.2014.12.026. Epub 2015 Jan 2.

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a major disease affecting pigs worldwide and resulting in considerable economic losses. While PRRS is a global phenomenon, the causative viruses PRRSV-1 (first detected in Europe) and PRRSV-2 (isolated in North America) are genetically and biologically distinct. In addition, the disease outcome is directly linked to co-infections associated with the porcine respiratory disease complex and the host response is variable between different breeds of pigs. It is therefore warranted when studying the pathogenesis of PRRS to consider each viral genotype separately and apply careful consideration to the disease model studied. We here review the respiratory pig model for PRRSV-1, with a focus on a recent set of studies conducted with carefully selected virus strains and pigs, which may serve as both a baseline and benchmark for future investigation.

Keywords: Disease model; Immune response; PRRSV.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Europe
  • Host-Pathogen Interactions*
  • North America
  • Porcine Reproductive and Respiratory Syndrome / pathology*
  • Porcine Reproductive and Respiratory Syndrome / virology*
  • Porcine respiratory and reproductive syndrome virus / classification
  • Porcine respiratory and reproductive syndrome virus / genetics
  • Porcine respiratory and reproductive syndrome virus / isolation & purification
  • Porcine respiratory and reproductive syndrome virus / physiology*
  • Swine
  • Swine Diseases / virology