Monitoring corneal hydration with a mid-infrared (IR) laser

Abhijeet Joshi; David B Bennett; Oscar M Stafsudd

doi:10.1016/j.jtos.2014.08.003

Monitoring corneal hydration with a mid-infrared (IR) laser

Ocul Surf. 2015 Jan;13(1):43-6. doi: 10.1016/j.jtos.2014.08.003. Epub 2014 Oct 19.

Authors

Abhijeet Joshi¹, David B Bennett², Oscar M Stafsudd³

Affiliations

¹ Department of Electrical Engineering, University of California, Los Angeles, CA, USA. Electronic address: abhijeet@ucla.edu.
² Department of Bio-Medical Engineering, University of California, Los Angeles, CA, USA.
³ Department of Electrical Engineering, University of California, Los Angeles, CA, USA.

PMID: 25557345
DOI: 10.1016/j.jtos.2014.08.003

Abstract

A mid-infrared (IR) source at ∼ 3 μm radiation is used as a probe to measure hydration in porcine cornea. Since the Er(3+):YAG emission targets vibrational modes (around 3300 cm(-1)) in the H2O molecule, it is highly sensitive to changes in water content in the first ∼ 10 μm of the corneal tissue.

Keywords: corneal hydration; hydration monitoring; mid-IR probe beam; terahertz imaging.

MeSH terms

Animals
Body Water / metabolism*
Cornea / chemistry*
Corneal Diseases / diagnosis
Corneal Diseases / metabolism*
Disease Models, Animal
Infrared Rays*
Lasers*
Monitoring, Physiologic / methods*
Swine