Catalytic asymmetric construction of pyrroloindolines via an in situ generated magnesium catalyst

Org Lett. 2015 Jan 16;17(2):176-9. doi: 10.1021/ol503455r. Epub 2014 Dec 31.

Abstract

An asymmetric formal [3 + 2]-cycloaddition between meso-aziridines and C3-alkylindoles mediated by an in situ generated magnesium catalyst was developed for asymmetric construction of pyrroloindolines. A variety of pyrroloindolines could be obtained by employing commercial available ligands with the assistance of an easily prepared achiral ligand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aziridines / chemistry*
  • Catalysis
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Ligands
  • Magnesium / chemistry*
  • Molecular Structure
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Stereoisomerism

Substances

  • Aziridines
  • Indoles
  • Ligands
  • Pyrroles
  • hexahydropyrrolo(2,3-b)indole
  • Magnesium