Spatial aspects of blood coagulation: two decades of research on the self-sustained traveling wave of thrombin

Konstantin Guria; Georgy Th Guria

doi:10.1016/j.thromres.2014.12.014

Spatial aspects of blood coagulation: two decades of research on the self-sustained traveling wave of thrombin

Thromb Res. 2015 Mar;135(3):423-33. doi: 10.1016/j.thromres.2014.12.014. Epub 2014 Dec 19.

Authors

Konstantin Guria¹, Georgy Th Guria²

Affiliations

¹ Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.
² Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia; National Research Center for Hematology, Moscow, 125167, Russia. Electronic address: guria@blood.ru.

PMID: 25550187
DOI: 10.1016/j.thromres.2014.12.014

Abstract

In a number of experimental studies, it has been demonstrated that the forefront of blood coagulation can propagate in the manner of a signal relay. These data strongly support the concept that the formation of a blood clot is governed by a self-sustained traveling wave of thrombin. The present review critically appraises the experimental data obtained in recent decades concerning the self-sustained spatial propagation of thrombin. Open questions regarding the experimental detection of the self-sustained propagation of thrombin are discussed.

Keywords: Blood coagulation; Spatial thrombus formation; Thrombin travelling waves.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Blood Coagulation Factors / analysis
Blood Coagulation Factors / metabolism
Blood Coagulation*
Blood Platelets / metabolism
Hemophilia A / metabolism
Hemophilia B / metabolism
Humans
Models, Biological
Signal Transduction
Thrombin / analysis
Thrombin / metabolism*

Substances

Blood Coagulation Factors
Thrombin